New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery—not just prevented or slowed—in animal models

A new study from Case Western Reserve University, University Hospitals, and the Louis Stokes Cleveland VA Medical Center has shown that Alzheimer's disease can be reversed in animal models. The research, published in Cell Reports Medicine, suggests that maintaining proper NAD+ balance can prevent and even reverse the disease. The study used preclinical mouse models and analysis of human AD brains to demonstrate that the brain’s failure to maintain normal levels of NAD+ is a major driver of AD. The team found that restoring NAD+ balance using a pharmacologic agent called P7C3-A20 enabled the brain to fix the major pathological events driven by the disease-causing genetic mutations and fully recover cognitive function.